《英文msh詞典》Class I Human Antigens
[入口詞] Class I Human Antigens
[主題詞] Histocompatibility Antigens Class I
[英文釋義] Large transmembrane,polymorphic glycoproteins noncovalently associated with nonpolymorphic beta 2-microglobulin. In humans,three structural genes on chromosome 6 code for the HLA-A; HLA-B and HLA-C antigens. In mice,three genes named K,D,and L on chromosome 17 code for the H-2 antigens. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during graft rejection and restrict cell-mediated lysis of virus-infected cells. They are primarily associated with rheumatologic diseases and certain malignant disorders.